Michael Minnick ( edit )

Professor

Contact Michael Minnick

Phone: (406) 243-5972
E-mail Address: mike.minnick@mso.umt.edu
Office : Health Sciences 509
Office Hours: I have an open door policy- students may come by any time.

Education

B.S. Walla Walla College, 1982
M.S. Walla Walla College, 1984
Ph.D. Washington State University, 1987

Teaching Experience

Washington State University-

· General Microbiology Laboratory (Micb 201)

Walla Walla College-

· General Biology (Biol 100)

The University of Montana-

· Medical Bacteriology and Mycology (BIOM 402)

· Medical Bacteriology and Mycology Laboratory (BIOM 403)

· General Microbiology (BIOM 360)

· General Microbiology Laboratory (BIOM 361)

· Medical Microbiology (Micb 302)

· Advanced Molecular Biology Lab (Micb 499)

· Elementary Medical Microbiology (Micb 106)

· Microbial Pathogenesis (Micb 540)

· Immunology (Micb 410)

· Immunology Laboratory (Micb 411)

· Advanced Immunology (Micb 502; graduate course)

· Montana NIH BRIN Molecular Biology Workshops, 2002, 2003

Research Interests

Ten Bartonella species are arthropod-borne, emerging infectious agents of human disease and are responsible for severe illnesses of the circulatory system (e.g., bacillary angiomatosis, hepatis peliosis, endocarditis, etc.). Fourteen additional Bartonella species infect a variety of other mammals including rodents, cats, dogs, livestock and wildlife. Our lab studies molecular and genetic aspects of the Bartonella – human and Bartonella - arthropod vector interfaces, with special emphasis on elucidating mechanisms contributing to: a) parasitism of erythrocytes and vascular endothelial cells, b) iron acquisition, c) pathological angiogenesis during infection and d) persistence within the human host and arthropod vector. Data from these studies are expected to contribute towards eventual control strategies.

Our lab also works with Coxiella burnetii- one of the most infectious bacterial pathogens known. Research on Coxiella focuses on understanding its complex developmental cycle, its unusual genetic elements (introns, ribozymes, inteins) and marked persistence in the environment. We are also developing novel approaches for treating Q fever. This research is designed to counter the potential bioterrorist threat imposed by the illegitimate use of C. burnetii. 

Professional Experience

9/01-present    Professor, Division of Biological Sciences, The University of Montana, Missoula, MT

9/00-9/06         Director, Murdock Molecular Biology Facility, The University of Montana, Missoula, MT

1/03-7/06,        Assistant Dean, Division of Biological Sciences, The University of Montana, Missoula

7/08-6/10         Assistant Dean, Division of Biological Sciences, The University of Montana, Missoula

1/98-9/00         Associate Director, Murdock Molecular Biology Facility, The University     of Montana, Missoula, MT

8/96-8/01         Associate Professor, Division of Biological Sciences, The University of Montana, Missoula, MT

8/91- 8/96        Assistant Professor, Division of Biological Sciences, The University of Montana, Missoula, MT   

6/90 - 7/91       Postdoctoral Fellow, Department of Molecular Biology, Battelle Pacific Northwest Laboratories, Richland, WA, with Dr. Marvin E. Frazier

l0/87 - 6/90      Postdoctoral Research Associate, Department of Microbiology, Washington State University, Pullman, WA, with Dr. Louis P. Mallavia

8/88 - 5/89       Instructor, Department of Microbiology, Washington State University, Pullman, WA

8/85 - 5/87       Graduate Teaching Assistant, Department of Microbiology, Washington State University, Pullman, WA

8/84 - 5/85       Graduate Research Assistant, Department of Microbiology, Washington State University, Pullman, WA

3/84 - 6/84       Instructor, Dept. of Biology, Walla Walla College, College Place, WA

l982 - l984       Graduate Teaching Assistant, Department of Biology, Walla Walla College, College Place, WA

l98l - l982         Undergraduate Teaching Assistant, Department of Biology, Walla Walla College, College Place, WA

Publications

SELECTED RECENT PUBLICATIONS-    

Parrow, N.L., J. Abbott, A.R. Lockwood, J.M. Battisti, and M.F. Minnick. 2009. Function, regulation, and transcriptional organization of the hemin utilization locus of Bartonella quintana. Infect. Immun. 77:307-316.

Raghavan, R., L.D. Hicks, and M.F. Minnick. 2009. A unique group I intron in Coxiella burnetii is a natural splice mutant. J. Bacteriol. 191:4044-4046.

 Minnick, M.F. and J.M. Battisti. 2009. Invited author. Pestilence, persistence and pathogenicity: infection strategies of Bartonella. Future Microbiol. 4:743-758.

Raghavan, R., and M.F. Minnick. 2009. Group I introns and inteins: disparate origins, but convergent parasitic strategies. J. Bacteriol. 191:6193-6202.

Hicks, L.D., R. Raghavan, J.M. Battisti, and M.F. Minnick. 2010. A DNA-binding peroxiredoxin of Coxiella burnetii is involved in countering oxidative stress during exponential-phase growth. J. Bacteriol. 192:2077-2084.   

Minnick, M.F., L.D. Hicks, J.M. Battisti and R. Raghavan. 2010. Pentamidine inhibits Coxiella burnetii growth and 23S rRNA intron splicing in vitro. Int. J. Antimicrob. Agents 36:380-382.

Battisti, J.M, L.D. Hicks and M.F. Minnick. 2011. A unique Coxiella burnetii lipoprotein involved in metal-binding (LimB). Microbiology 157:966-976.

Hicks, L.D., I. Warrier, R. Raghavan, and M.F. Minnick. 2011. Ribozyme stability, exon skipping and potential role for RNA helicase in group I intron splicing by Coxiella burnetii. J. Bacteriol. 193:5292-5299.

Wright, B.E., K. Schmidt, A.T. Hunt. J.S. Lodmell, M.F. Minnick and D. Reschke. 2011. The roles of transcription and genotoxins underlying p53 mutagenesis in vivo. Carcinogenesis. 32:1559-1567.

Minnick, M.F. and R. Raghavan. 2011. Invited author. Genetics of Coxiella burnetii: on the path of specialization. Future Microbiol. 6:1297-1314.

Wright, B.E., K.H. Schmidt, A.T. Hunt, D.K. Reschke, and M.F. Minnick. 2011. The evolution of coordinated mutagenesis and somatic hypermutation in VH5. Mol. Immunol. 49:537-548.

Wright, B.E., K.H. Schmidt and M.F. Minnick. 2013. Kinetic models reveal the in vivo mechanisms of mutagenesis in microbes and man. Mutat. Res. 752:129-137.

Parrow, N.L., R.E. Fleming and M.F. Minnick. 2013. Sequestration and scavenging: iron in infection. Infect. Immun. 81:3503-3514.

Warrier, I., L. Hicks, J.M. Battisti, R. Raghavan, and M.F. Minnick. 2014. Identification of novel small RNAs and characterization of the 6S RNA of Coxiella burnetii. PLoS ONE 9: e100147.

Minnick, M.F., B.E. Anderson, A. Lima, J.M. Battisti, P.G. Lawyer and R.J.Birtles. 2014. Oroya fever and verruga peruana: Bartonelloses unique to South America. PLoS Negl. Trop. Dis. 8: e2919.

Affiliations

American Society for Microbiology

American Society for Rickettsiology (past president)

Field of Study

Microbial pathogenesis

International Experience

Consultant to Peruvian National Institutes of Health for development of a vaccine against Carrion's disease.

Courses Taught

· Medical Bacteriology and Mycology (BIOM 402)

· Medical Bacteriology and Mycology Laboratory (BIOM 403)

· General Microbiology (BIOM 360)

· General Microbiology Laboratory (BIOM 361)

· Microbial Pathogenesis (Micb 540)

Honors

Editorial Board, Fine Focus, 2014-present

Outstanding Faculty Advising Award (for undergraduate advising), The University of Montana, 2012

Student Affairs, Faculty Recognition Award, UM, 2012

Honorary Member, Gold Key International Honour Society, 2011-

Editorial Review Board, Frontiers in Cellular and Infection Microbiology, 2010-present

Ad Hoc Reviewer, NIH-NIAID; Bacterial Pathogenesis (ZRG1), 2009

Editorial Board, Journal of Microbiological Methods, 2007-present

Publication selected for Faculty of 1000 Biology, 2007 (Battisti et al., 2007)

Student Affairs Faculty Recognition Award, The University of Montana, 2007

Ad Hoc Reviewer, NIH-NIAID; Topics in Microbial Pathogenesis (ZRG1), 2006

Ad Hoc Reviewer, NIH-NIAID; Bacterial Pathogenesis (ZRG1), 2005

Ad Hoc Reviewer, NIH-NIAID; Bacteriology & Mycology I (BM1), 2004

Ad Hoc Reviewer, NIH-NIAID; Viral and Eukaryotic Pathogens (ZRG1), 2004

Ad Hoc Reviewer, NIH-NIAID; Biodefense & Emerging Infectious Disease (ZAI1), 2003

Ad Hoc Reviewer, NIH-NIAID; Illegitimate Use of Bacterial Pathogens (ZAI1), 2001

Ad Hoc Reviewer, NIH-NIAID; Bacteriology & Mycology I (BM1), 2000

Faculty Merit Awards, UM- 1994, 1995, 1998, 2000, 2003, 2004, 2008, 2010, 2012

Outstanding Faculty Recognition Award, UM Greek Life, 2003

Tenure, The University of Montana, 1997

Winston and Helen Cox Teaching Award, The University of Montana, 1995

Department of Energy (NORCUS) Postdoctoral Fellowship, 1990-1991

Washington State University Competitive Summer Research Assistantship, 1987

Victor Burke Memorial Fellowship, Washington State University, l985, l986

Dean's Award for Academic Excellence, Walla Walla College, l984

Graduation Cum Laude, Walla Walla College,  l982

Outstanding Biology Graduate, Walla Walla College, l982