Table of Contents

index
Announcements
Questions
Section 6.7: Serine Proteases
Substrate Specificity of Serine Proteases
Specificity of Substrate Binding Site
The Catalytic Triad
The Detailed Reaction Mechanism
Step 1: Peptide Docking (1.0)
Step 1: Peptide Docking (1.1)
Step 2: Formation of Transition State (2.0)
Step 2: Formation of Transition State (2.1.0)
Step 2: Formation of Transition State (2.1.1)
Step 2: Formation of Transition State (2.1.2)
Step 2: Formation of Transition State (2.2.0)
Step 2: Formation of Transition State (2.2.1)
Step 2: Formation of Transition State (2.2.2)
Step 2: Formation of Transition State (2.2.3)
Step 2: Formation of Transition State (2.3.0)
Step 2: Formation of Transition State (2.3.1)
Step 2: Formation of Transition State (2.3.2)
Step 2: Formation of Transition State (2.3.3)
Step 2: Formation of Transition State (2.3.4)
Step 2: Formation of Transition State (2.4.0)
Step 2: Formation of Transition State (2.4.1)
Step 2: Formation of Transition State (2.4.2)
Step 2: Formation of Transition State (2.4.3)
Step 3: Peptide Bond Cleavage (3.0.0)
Step 3: Peptide Bond Cleavage (3.0.1)
Step 3: Peptide Bond Cleavage (3.0.2)
Step 3: Peptide Bond Cleavage (3.1.0)
Step 3: Peptide Bond Cleavage (3.1.1)
Step 3: Peptide Bond Cleavage (3.1.2)
Step 3: Peptide Bond Cleavage (3.1.3)
Step 3: Peptide Bond Cleavage (3.1.4)
Step 3: Peptide Bond Cleavage (3.2.0)
Step 3: Peptide Bond Cleavage (3.2.1)
Step 3: Peptide Bond Cleavage (3.2.2)
Step 3: Peptide Bond Cleavage (3.2.3)
Step 4: Binding of Water, Formation of Second Intermediate (4.0.0)
Step 4: Binding of Water, Formation of Second Intermediate (4.0.1)
Step 4: Binding of Water, Formation of Second Intermediate (4.0.2)
Step 4: Binding of Water, Formation of Second Intermediate (4.0.3)
Step 4: Binding of Water, Formation of Second Intermediate (4.1.0)
Step 4: Binding of Water, Formation of Second Intermediate (4.1.1)
Step 4: Binding of Water, Formation of Second Intermediate (4.1.2)
Step 4: Binding of Water, Formation of Second Intermediate (4.1.3)
Step 4: Binding of Water, Formation of Second Intermediate (4.1.4)
Step 4: Binding of Water, Formation of Second Intermediate (4.2.0)
Step 4: Binding of Water, Formation of Second Intermediate (4.2.1)
Step 4: Binding of Water, Formation of Second Intermediate (4.2.2)
Step 5: Cleavage of Second Intermediate
Step 5: Cleavage of Second Intermediate
Step 5: Cleavage of Second Intermediate
Step 5: Cleavage of Second Intermediate
Step 5: Cleavage of Second Intermediate
Step 5: Cleavage of Second Intermediate
Step 5: Cleavage of Second Intermediate
Step 6: Release of Carboxylate Product (6.0.0)
Step 6: Release of Carboxylate Product (6.0.1)
Step 6: Release of Carboxylate Product (6.0.2)
Step 6: Release of Carboxylate Product (6.0.3)
Step 6: Release of Carboxylate Product (6.0.4)
Step 6: Release of Carboxylate Product (6.0.5)
Questions
Next Lecture: Sections 7.1 - 7.3