Models of Allosteric Regulation
- There are two main models that attempt to describe the cooperative effects of allosteric binding
for multimeric enzymes
- The two models are the concerted (MWC) model and the sequential (Koshland) model
- Both models attempt to provide a quantitative description of changes from the T to the R state
for all subunits in a complex, with varying degrees of success, depending upon the particular enzyme
- For many enzymes, the behavior is complex and can only be adequately described by combining
aspects from both models