Classical Noncompetitive Inhibition
- In classical noncompetitive inhibition, the substrate and the inhibitor can both be bound to the enzyme at
the same time, but the bound inhibitor renders the enzyme inactive
- This reduces the effective Vmax, but since substrate binding is not affected by the inhibitor,
the Km value remains the same
- In general, the effect of inhibitors can be more complex, with both Km and Vmax being affected.
Such cases are referred to as mixed inhibition