Allosteric Regulation of Hemoglobin
- Allosteric regulation is an important mechanism of hemoglogin and is also used extensively in the
control of enzyme activity. Allosteric means 'other site' and refers the the effect of small molecules that
bind at sites other than the active site of the molecule
- In hemoglobin, the molecule 2-3-bisphosphoglycerate (2,3BPG) is a negatively-charged allosteric effector
that binds to a positively-charged central region, stabilizing hemoglogin in the T state and promoting
unloading of oxygen in tissues