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Chapter 4: Protein Structure
Proteomics
Section 4.1: Levels of Protein Structure
Secondary Structure
Tertiary Structure
Quaternary Structure
Section 4.2: Techniques for Determining 3D Structure
X-Ray Crystallography
Producing Crystal Structures
X-Ray Diffraction
Model Construction
NMR
Principles of NMR
One-Dimensional NMR
2D NMR
NMR Distance Constraints
Multiple NMR Structures
Section 4.3: Protein Residue Conformation
Planarity of the Peptide Bond
Cis and Trans Configurations
Parameters of Protein Conformation
Protein Conformational Space
Ramachandran Diagrams
Questions
References
Next Lecture: Sections 4.4 - 4.6